For over 60 years since the foundation, Sansho Pharmaceutical has been committed to the research and development of skin care ingredients. In this report, we present you one of the well-received ingredients we developed.
From the laboratory
Little-known power of Kojic Acid
As you age, skin tone changes to brownish yellow. This is because of AGEs (Advanced Glycation End Products) produced in glycation, a reaction of bonding proteins such as collagen and carbohydrate, which can happen in anyone’s body. AGEs, brownish yellow substance, tend to accumulate more and change skin tone to brownish yellow as you age.
Clinical studies showed that Kojic Acid effectively lightened skin tone. Therefore we conducted studies once again and found out that it also inhibits AGEs production significantly.
1 | 肝斑患者に対するコウジ酸配合製剤の使用成績. The Nishinihon Journal of Dermatology Vol. 44(3), 474-478 |
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2 | コウジ酸配合製剤の使用経験:—女子の顔面色素増加症にたいする治療効果— The Nishinihon Journal of Dermatology Vol. 44(3), 470-473 |
3 | Kojic Acid外用による肝斑の治療. Japanese Journal of Clinical Dermatology Vol. 36(7), 715-722 |
4 | コウジ酸のmelanin生成抑制作用について. Fragrance Journal No.63, 40-44 |
5 | Pigmentation in aging and melanogenic inhibitors. Fragrance Journal Vol.17(1), 25-33 |
6 | Therapy of chloasma. Practical Dermatology Vol.12(7), 625-640 |
7 | シミの新しい治療法. Journal of Japan Hair Beauty Association Vol.3 |
8 | 特集「コウジ酸クリームのシミ予防効果」 The Pharmacy companion Vol.16(2) |
9 | Melanogenesis-inhibitory effect of kojic Acid and its action mechanism. Fragrance Journal Vol.18(6), 53-58 |
10 | Inhibitory Action of Kojic Acid on Melanogenesis and Its Therapeutic Effect for Various Human Hyper-Pigmentation Disorders. Skin Research Vol.36(2), 134-150 |
11 | Clinical Effect of a Kojic Acid Containg Cream on Hyperpigmentaion of the Skin. Skin Research Vol.36(5), 707-714 |
12 | The Effect of Kojic Acid Application on Various Facial Pigmentary Disorders. The Nishinihon Journal of Dermatology Vol.56(6), 1172-1181 |
13 | Further studies on the therapeutic effect of a new composite type of kojic acid cream on human hyper-pigmentary disorders. Fragrance Journal Vol.14, 113-137 |
14 | 美白剤の評価‐コウジ酸について The Journal of Japan Hair Science Association Vol.28 No.4 |
15 | The Effect of Long-term Usage of Kojic Acid Cream. The Nishinihon Journal of Dermatology Vol.60(6) |
16 | Cosmeceuticals Drugs vs. Cosmetics P. Elsner H. I. Maibach |
17 | Prevention of the photodamage in the hairless mouse dorsal skin by kojic acid as an iron chelator European J of Pharmacol. 411 |
18 | Review of Liver Function, Tumor Marker and Tumors after Long-term Topical Use of 1% Kojic Acid Cream. The Nishinihon Journal of Dermatology Vol.67(4), 412-415 |
19 | Side effect and utility of a cosmetic. J.JOCD No.47, 38-43 |
20 | コウジ酸の生合成遺伝子,麹菌培養条件に応答した遺伝子発現機構 発酵・醸造食品の最新技術と機能性 Ⅱ |